Neurosciences
The Neurosciences Research Domain (NeRD) aims to understand neural structure and function in normal conditions and disease, using a multidisciplinary and integrative approach, from fundamental to clinical studies. Our scientists strive to comprehend how complex neural circuits work, how these are shaped and reshaped during life by different environmental factors and how this drives behaviour. Also, we are focused on understanding the neurobiological mechanisms implicated in several neurodevelopmental and neurodegenerative disorders, as well as in evaluating the interplay between the nervous and the immune systems.
ICVS
Neurosciences Publications
Sorting nexin 3 mutation impairs development and neuronal function in Caenorhabditis elegans
Vieira N, Bessa C, Rodrigues AJ, Marques P, Chan FY, de Carvalho AX, Correia-Neves M, Sousa N. Sorting nexin 3 mutation impairs development and neuronal function in...
Read moreEndolysosomal degradation of Tau and its role in glucocorticoid-driven hippocampal malfunction
Vaz-Silva J, Gomes P, Jin Q, Zhu M, Zhuravleva V, Quintremil S, Meira T, Silva J, Dioli C, Soares-Cunha C, Daskalakis NP, Sousa N, Sotiropoulos I, Waites CL...
Read moreInflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset Alzheimer disease: a post mortem study
Taipa R, Ferreira V, Brochado P, Robinson A, Reis I, Marques F, Mann DM, Melo-Pires M, Sousa N. Inflammatory pathology markers (activated microglia and reactive...
Read moreBrain morphometric profiles and their seasonal modulation in fish (Liza aurata) inhabiting a mercury contaminated estuary
Puga S, Cardoso V, Pinto-Ribeiro F, Pacheco M, Almeida A, Pereira P. Brain morphometric profiles and their seasonal modulation in fish (Liza aurata) inhabiting a...
Read moreEmotional distress in haemophilia: Factors associated with the presence of anxiety and depression symptoms among adults
Pinto PR, Paredes AC, Moreira P, Fernandes S, Lopes M, Carvalho M, Almeida A. Emotional distress in haemophilia: Factors associated with the presence of anxiety and...
Read morePsychological factors predict an unfavorable pain trajectory after hysterectomy: a prospective cohort study on chronic post-surgical pain
Pinto PR, McIntyre T, Araújo-Soares V, Almeida A, Costa P. Psychological factors predict an unfavorable pain trajectory after hysterectomy: a prospective cohort study...
Read moreDichotomous parvalbumin interneuron populations in dorsolateral and dorsomedial striatum
Monteiro P, Barak B, Zhou Y, McRae R, Rodrigues D, Wickersham IR, Feng G. Dichotomous parvalbumin interneuron populations in dorsolateral and dorsomedial...
Read moreNeuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures
Miranda AM, Lasiecka ZM, Xu Y, Neufeld J, Shahriar S, Simoes S, Chan RB, Oliveira TG, Small SA, Di Paolo G. Neuronal lysosomal dysfunction releases exosomes harboring...
Read moreDisruption of the β1L isoform of GABP reverses glioblastoma replicative immortality in a TERT promoter mutation-dependent manner
Mancini A, Xavier-Magalhães A, Woods WS, Nguyen KT, Amen AM, Hayes JL, Fellmann C, Gapinske M, McKinney AM, Hong C, Jones LE, Walsh KM, Bell RJA, Doudna JA, Costa BM...
Read moreThe dynamics of stress: a longitudinal MRI study of rat brain structure and connectome
Magalhães R, Barrière DA, Novais A, Marques F, Marques P, Cerqueira J, Sousa JC, Cachia A, Boumezbeur F, Bottlaender M, Jay TM, Mériaux S, Sousa N. The dynamics of...
Read moreWNT6 is a Novel Oncogenic Prognostic Biomarker in Human Glioblastoma
Gonçalves CS, Vieira de Castro J, Pojo M, Martins EP, Queirós S, Chautard E, Taipa R, Pires MM, Pinto AA, Pardal F, Custódia C, Faria CC, Clara C, Reis RM, Sousa N...
Read moreCo-Transplantation of Adipose Tissue-Derived Stromal Cells and Olfactory Ensheathing Cells for Spinal Cord Injury Repair
Gomes ED, Mendes SS, Assunção-Silva RC, Teixeira FG, Pires AO, Anjo SI, Manadas B, Leite-Almeida H, Gimble JM, Sousa N, Lepore AC, Silva NA, Salgado AJ...
Read moreLipocalin-2 regulates adult neurogenesis and contextual discriminative behaviours
Ferreira AC, Santos T, Sampaio-Marques B, Novais A, Mesquita SD, Ludovico P, Bernardino L, Correia-Neves M, Sousa N, Palha JA, Sousa JC, Marques F. Lipocalin-2...
Read morePreclinical evidence supporting early initiation of citalopram treatment in Machado-Joseph disease
Esteves S, Oliveira S, Duarte-Silva S, Cunha-Garcia D, Teixeira-Castro A, Maciel P. Preclinical evidence supporting early initiation of citalopram treatment in...
Read moreFunctional Hemispheric (A)symmetries in the Aged Brain-Relevance for Working Memory
Esteves M, Magalhães R, Marques P, Castanho TC, Portugal-Nunes C, Soares JM, Almeida A, Santos NC, Sousa N, Leite-Almeida H. Functional Hemispheric (A)symmetries in...
Read moreNeuroprotective Effects of Creatine in the CMVMJD135 Mouse Model of Spinocerebellar Ataxia Type 3
Duarte-Silva S, Neves-Carvalho A, Soares-Cunha C, Silva JM, Teixeira-Castro A, Vieira R, Silva-Fernandes A, Maciel P. Neuroprotective Effects of Creatine in the...
Read moreImpairments in laterodorsal tegmentum to VTA projections underlie glucocorticoid-triggered reward deficits
Coimbra B, Soares-Cunha C, Borges S, Sousa N, Rodrigues AJ. Impairments in laterodorsal tegmentum to VTA projections underlie glucocorticoid-triggered reward...
Read moreTime matters in multiple sclerosis: can early treatment and long-term follow-up ensure everyone benefits from the latest advances in multiple sclerosis?
Cerqueira JJ, Compston DAS, Geraldes R, Rosa MM, Schmierer K, Thompson A, Tinelli M, Palace J. Time matters in multiple sclerosis: can early treatment and long-term...
Read moreChronic stress targets adult neurogenesis preferentially in the suprapyramidal blade of the rat dorsal dentate gyrus.
Alves ND, Patrício P, Correia JS, Mateus-Pinheiro A, Machado-Santos AR, Loureiro-Campos E, Morais M, Bessa JM, Sousa N, Pinto L. Chronic stress targets adult...
Read moreIntra-axonal Synthesis of SNAP25 Is Required for the Formation of Presynaptic Terminals
Batista AFR, Martinez JC, Hengst U. Intra-axonal Synthesis of SNAP25 Is Required for the Formation of Presynaptic Terminals. Cell Reports...
Read moreAdenosine A2A receptor regulation of microglia morphological remodeling-gender bias in physiology and in a model of chronic anxiety
Caetano L, Pinheiro H, Patrício P, Mateus-Pinheiro A, Alves ND, Coimbra B, Baptista FI, Henriques SN, Cunha C, Santos AR, Ferreira SG, Sardinha VM...
Read moreImpairments in laterodorsal tegmentum to VTA projections underlie glucocorticoid triggered reward deficits
Coimbra B, Soares-Cunha C, Borges S, Vasconcelos NAP, Sousa N, Rodrigues AJ. Impairments in laterodorsal tegmentum to VTA projections underlie glucocorticoid...
Read moreTau-dependent suppression of adult neurogenesis in the stressed hippocampus
Dioli C, Patrício P, Trindade R, Pinto LG, Silva JM, Morais M, Ferreiro E, Borges S, Mateus-Pinheiro A, Rodrigues AJ, Sousa N, Bessa JM, Pinto L, Sotiropoulos I...
Read moreStructural laterality is associated with cognitive and mood outcomes: An assessment of 105 healthy aged volunteers
Esteves M, Marques P, Magalhães R, Castanho TC, Soares JM, Almeida A, Santos NC, Sousa N, Leite-Almeida H. Structural laterality is associated with cognitive and mood...
Read moreDiscovery of Therapeutic Approaches for Polyglutamine Diseases: A Summary of Recent Efforts
Esteves S, Duarte-Silva S, Maciel P. Discovery of Therapeutic Approaches for Polyglutamine Diseases: A Summary of Recent Efforts. Medicinal Research Reviews...
Read moreInput-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory
Leroy F, Brann DH, Meira T, Siegelbaum SA. Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory. Neuron...
Read moreTau Deletion Prevents Stress-Induced Dendritic Atrophy in Prefrontal Cortex: Role of Synaptic Mitochondria
Lopes S, Teplytska L, Vaz-Silva J, Dioli C, Trindade R, Morais M, Webhofer C, Maccarrone G, Almeida OFX, Turck CW, Sousa N, Sotiropoulos I, Filiou...
Read moreIdentification of octopaminergic neurons that modulate sleep suppression by male sex drive
Machado DR, Afonso DJ, Kenny AR, Öztu Rk-Çolak A, Moscato EH, Mainwaring B, Kayser M, Koh K. Identification of octopaminergic neurons that modulate sleep suppression...
Read moreIntegrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma
Mackay A, Burford A, (…) Reis RM, (…) Resnick A, Jones C. Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine...
Read moreAP2γ controls adult hippocampal neurogenesis and modulates cognitive, but not anxiety or depressive-like behavior
Mateus-Pinheiro A, Alves ND, Patricio P, Machado-Santos AR, Campos E, Silva J, Sardinha V, Reis, J, Schorle H, Oliveira JF, Ninkovic J, Sousa N, Pinto L...
Read moreSHANK proteins: roles at the synapse and in autism spectrum disorder
Monteiro P, Feng G. SHANK proteins: roles at the synapse and in autism spectrum disorder. Nature Reviews Neuroscience 18(3):147-157 (2017)
Read moreBrain interference: Revisiting the role of IFNγ in the central nervous system
Monteiro S, Roque S, Marques F, Correia-Neves M, Cerqueira JJ. Brain interference: Revisiting the role of IFNγ in the central nervous system. Progress in...
Read moreMicrofluidic immunosensor for rapid and highly-sensitive salivary cortisol quantification
Pinto V, Sousa P, Catarino SO, Correia-Neves M, Minas G. Microfluidic immunosensor for rapid and highly-sensitive salivary cortisol...
Read moreOld and new challenges in Parkinson’s disease therapeutics
Pires AO, Teixeira FG, Mendes-Pinheiro B, Serra SC, Sousa N, Salgado AJ. Old and new challenges in Parkinson’s disease therapeutics. Progress in...
Read moreThe choroid plexus as a sex hormone target: Functional implications
Santos CR, Duarte AC, Quintela T, Tomás J, Albuquerque T, Marques F, Palha JA, Gonçalves I. The choroid plexus as a sex hormone target: Functional...
Read moreAstrocytic signaling supports hippocampal–prefrontal theta synchronization and cognitive function
Sardinha VM, Guerra-Gomes S, Caetano I, Tavares G, Martins M, Reis JS, Correia JS, Teixeira-Castro A, Pinto L, Sousa N, Oliveira JF. Astrocytic signaling...
Read moreMesenchymal Stem Cell Secretome: A Potential Tool for the Prevention of Muscle Degenerative Changes Associated With Chronic Rotator Cuff Tears
Sevivas N, Teixeira FG, Portugal R, Araújo L, Carriço LF, Ferreira N, Vieira da Silva M, Espregueira-Mendes J, Anjo S, Manadas B, Sousa N, Salgado AJ...
Read moreDistribution of amyloid-like and oligomeric species from protein aggregation kinetics
Silva A, Almeida B, Fraga JS, Taboada P, Martins PM, Macedo-Ribeiro S. Distribution of amyloid-like and oligomeric species from protein aggregation...
Read moreCalcineurin Dysregulation Underlies Spinal Cord Injury-Induced K+ Channel Dysfunction in DRG Neurons
Zemel BM, Muqeem T, Brown EV, Goulão M, Urban MW, Tymanskyj SR, Lepore AC, Covarrubias M. Calcineurin Dysregulation Underlies Spinal Cord Injury-Induced K+...
Read moreS100B as a Potential Biomarker and Therapeutic Target in Multiple Sclerosis
Barateiro A, Afonso V, Santos G, Cerqueira JJ, Brites D, van Horssen J, Fernandes A. S100B as a Potential Biomarker and Therapeutic Target in Multiple...
Read moreThe prognostic impact of TERT promoter mutations in glioblastomas is modified by the rs2853669 single nucleotide polymorphism
Batista R, Cruvinel-Carloni A, Vinagre J, Peixoto J, Catarino TA, Campanella NC, Menezes W, Becker AP, Caravina GA, Matsushita MM, Clara C, Neder...
Read moreRepeated administration of a synthetic cannabinoid receptor agonist differentially affects cortical and accumbal neuronal morphology in adolescent and adult rats
Carvalho AF, Reyes BA, Ramalhosa F, Sousa N, Van Bockstaele EJ. Repeated administration of a synthetic cannabinoid receptor agonist differentially...
Read moreCombination of a peptide-modified gellan gum hydrogel with cell therapy in a lumbar spinal cord injury animal model
Gomes ED, Mendes SS, Leite-Almeida H, Gimble JM, Tam RY, Shoichet MS, Sousa N, Silva NA, Salgado AJ. Combination of a peptide-modified gellan gum hydrogel with...
Read moreProtein Prenylation Constitutes an Endogenous Brake on Axonal Growth
Li H, Kuwajima T, Oakley D, Nikulina E, Hou J, Yang WS, Lowry ER, Lamas NJ, Amoroso MW, Croft GF, Hosur R, Wichterle H, Sebti S, Filbin MT, Stockwell B...
Read moreIdentification of novel genetic causes of Rett syndrome-like phenotypes
Lopes F, Barbosa M, Ameur A, Soares G, de Sá J, Dias AI, Oliveira G, Cabral P, Temudo T, Calado E, Cruz IF, Vieira JP, Oliveira R, Esteves S, Sauer S, Jonasson...
Read moreAbsence of Tau triggers age-dependent sciatic nerve morphofunctional deficits and motor impairment
Lopes S, Lopes A, Pinto V, Guimarães MR, Sardinha MR, Duarte-Silva S, Pinheiro S, Pizarro J, Oliveira JF, Sousa N, Leite-Almeida H, Sotiropoulos I. Absence of...
Read moreTau protein is essential for stress-induced brain pathology
Lopes S, Vaz-Silva J, Pinto V, Dalla C, Kokras N, Bedenk B, Mack N, Czisch M, Almeida OFX, Sousa N, Sotiropoulos I. Tau protein is essential for...
Read moreInsights on the pathophysiology of Alzheimer’s disease: the crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system
Mesquita SD, Ferreira AC, Sousa JC, Correia-Neves M, Sousa N, Marques F. Insights on the pathophysiology of Alzheimer’s disease: the crosstalk between amyloid...
Read moreAbsence of IFNg promotes hippocampal plasticity and enhances cognitive performance
Monteiro S, Ferreira FM, Pinto V, Roque S, Sá-Calçada D, Morais M, Sousa N, Correia-Neves M, Cerqueira JJ. Absence of IFNg promotes hippocampal plasticity and...
Read moreIdentifying Functional Subdivisions in the Medial Frontal Cortex
Moreira PS, Marques P, Magalhães R. Identifying Functional Subdivisions in the Medial Frontal Cortex. Journal of Neuroscience 36(44):11168-11170 (2016)
Read moreThe impact of chronic stress on the rat brain lipidome
Oliveira TG, Chan RB, Bravo FV, Miranda A, Silva RR, Zhou B, Marques F, Pinto V, Cerqueira JJ, Di Paolo G, Sousa N. The impact of chronic stress on the...
Read moreTau mislocation in glucocorticoid-triggered hippocampal pathology
Pinheiro S, Silva J, Mota C, Vaz-Silva J, Veloso A, Pinto V, Sousa N, Cerqueira J, Sotiropoulos I. Tau mislocation in glucocorticoid-triggered hippocampal...
Read moreActivation of D2 dopamine receptor-expressing neurons in the nucleus accumbens increases motivation
Soares-Cunha C, Coimbra B, David-Pereira A, Borges S, Pinto L, Costa P, Sousa N, Rodrigues AJ. Activation of D2 dopamine receptor-expressing neurons in the nucleus...
Read moreReappraising striatal D1- and D2-neurons in reward and aversion
Soares-Cunha C, Coimbra B, Sousa N, Rodrigues AJ. Reappraising striatal D1- and D2-neurons in reward and aversion. Neuroscience and Biobehavioral Reviews...
Read moreThe dynamics of the stress neuromatrix
Sousa N. The dynamics of the stress neuromatrix. Molecular Psychiatry 21(3):302-312 (2016)
Read moreModulation of the Mesenchymal Stem Cell Secretome Using Computer-Controlled Bioreactors: Impact on Neuronal Cell Proliferation, Survival and Differentiation
Teixeira FG, Panchalingam KM, Assunção-Silva R, Serra SC, Mendes-Pinheiro B, Patrício P, Jung S, Anjo SI, Manadas B, Pinto L, Sousa N, Behie LA...
Read moreBioengineered cell culture systems of central nervous system injury and disease
Teixeira FG, Vasconcelos NL, Gomes ED, Marques F, Sousa JC, Sousa N, Silva NA, Assunção-Silva R, Lima R, Salgado AJ. Bioengineered cell culture systems of...
Read moreRecurrent copy number variations as risk factors for neurodevelopmental disorders: critical overview and analysis of clinical implications
Torres F, Barbosa M, Maciel P. Recurrent copy number variations as risk factors for neurodevelopmental disorders: critical overview and analysis of clinical...
Read moreTARANIS Functions with Cyclin A and Cdk1 in a Novel Arousal Center to Control Sleep in Drosophila
Afonso DJS, Liu D, Machado DR, Pan H, Jepson JEC, Rogulja D, Koh K. TARANIS Functions with Cyclin A and Cdk1 in a Novel Arousal Center to Control Sleep in...
Read moreThe effect of high fat diet on rat’s mood, feeding behavior and response to stress
Aslani S, Vieira N, Marques F, Costa PS, Sousa N, Palha JA. The effect of high fat diet on rat’s mood, feeding behavior and response to stress. Translational...
Read moreMethylation at the CpG island shore region upregulates Nr3c1 promoter activity after early-life stress
Bockmühl Y, Patchev AV, Madejska A, Hoffmann A, Sousa JC, Sousa N, Holsboer F, Almeida OFX, Spengler D. Methylation at the CpG island shore region upregulates...
Read moreThe Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3′-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis
Chatterjee A, Saha S, Silva-Fernandes A, Mandal SM, Neves-Carvalho A, Liu Y, Pandita RK, Chakraborty A, Hegde ML, Hegde PM, Boldogh I, Ashizawa T, Koeppen...
Read moreSilencing of the tumor suppressor gene WNK2 is associated with upregulation of MMP2 and JNK in gliomas
Costa AM, Pinto F, Martinho O, Oliveira MJ, Jordan P, Reis RM. Silencing of the tumor suppressor gene WNK2 is associated with upregulation of MMP2 and JNK...
Read moreFrom the periphery to the brain: lipocalin-2, a friend or foe?
Ferreira AC, Mesquita SD, Sousa JC, Correia-Neves M, Sousa N, Palha JA, Marques F. From the periphery to the brain: lipocalin-2, a friend or foe? Progress...
Read moreInactivation of PNKP by mutant ATXN3 triggers apoptosis by activating the DNA damage-response pathway in SCA3
Gao R, Liu Y, Silva-Fernandes A, Paulucci-Holthauzen A, Chatterjee A, Zhang H, Mattsura T, Fang X, Choudhary S, Ashizawa T, Koeppen A, Maciel P, Hazra TK...
Read moreBrain activation of the defensive and appetitive survival systems in obsessive compulsive disorder
Gonçalves OF, Soares JM, Carvalho S, Leite J, Ganho A, Fernandes-Gonçalves A, Frank B, Pocinho F, Relvas J, Carracedo A, Sampaio A. Brain activation of the...
Read moreThe bounds of education in the human brain connectome
Marques P, Soares JM, Magalhães R, Santos NC, Sousa N. The bounds of education in the human brain connectome. Scientific Reports...
Read moreThe positive effect on ketamine as a priming adjuvant in antidepressant treatment
Melo A, Kokras N, Dalla C, Ferreira C, Ventura-Silva AP, Sousa N, Pêgo JM. The positive effect on ketamine as a priming adjuvant in antidepressant...
Read moreThe choroid plexus transcriptome reveals changes in type I and II interferon responses in a mouse model of Alzheimer’s Disease
Mesquita SD, Ferreira AC, Gao F, Coppola G, Geschwind DH, Sousa JC, Correia-Neves M, Sousa N, Palha JA, Marques F. The choroid plexus transcriptome...
Read moreLipids under stress – a lipidomic approach for the study of mood disorders
Miranda AM, Oliveira TG. Lipids under stress – a lipidomic approach for the study of mood disorders. Bioessays 37(11):1226-1235 (2015)
Read moreDominant negative effect of polyglutamine expansion perturbs normal function of ataxin-3 in neuronal cells
Neves-Carvalho A, Logarinho E, Freitas A, Duarte-Silva S, Costa MC, Silva-Fernandes A, Martins M, Cravino Serra S, Lopes A, Paulson HL...
Read moreDo stars govern our actions? Astrocyte involvement in rodents’ behavior
Oliveira J, Sardinha V, Guerra-Gomes S, Araque A, Sousa N. Do stars govern our actions? Astrocyte involvement in rodents’ behavior. Trends in Neurosciences...
Read moreDifferential and converging molecular mechanisms of antidepressants action in the hippocampal dentate gyrus.
Patrício P, Mateus-Pinheiro A, Irmler M, Alves ND, Machado-Santos AR, Morais M, Correia JS, Korostynski M, Piechota M, Stoffel R, Beckers J, Bessa JM...
Read moreDifferential impact of chronic stress along the hippocampal dorsal-ventral axis
Pinto V, Costa JC, Morgado P, Mota C, Miranda A, Bravo FV, Oliveira TG, Cerqueira JJ, Sousa N. Differential impact of chronic stress along the hippocampal...
Read moreExpression of histone methyltransferases as novel biomarkers for renal cell tumor diagnosis and prognostication
Pires-Luís AS, Vieira-Coimbra M, Vieira FQ, Costa-Pinheiro P, Silva-Santos R, Dias PC, Antunes L, Lobo F, Oliveira J, Gonçalves CS, Costa BM, Henrique R...
Read moreA transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide.
Pojo M, Gonçalves CS, Xavier-Magalhães A, Oliveira AI, Gonçalves T, Correia S, Rodrigues AJ, Costa S, Pinto L, Pinto AA, Lopes JM, Reis RM, Rocha...
Read moreNovel candidate blood-based transcriptional biomarkers of Machado-Joseph disease (MJD/SCA3).
Raposo M, Bettencourt C, Gao F, Ramos A, Kazachkova N, Vasconcelos J, Kay T, Rodrigues AJ, Maciel P, Bettencourt B, Bruges-Armas J, Geschwind D, Coppola G...
Read moreSerotonergic signalling suppresses ataxin-3 aggregation and neurotoxicity in animal models of Machado-Joseph disease
Teixeira-Castro A, Jalles AL, Esteves S, Kang S, Santos L, Silva-Fernandes A, Neto M, Brielmann RM, Bessa C, Miranda A, Oliveira...
Read moreOptimization of a Pentaplex Panel for MicroSatellite Instability (MSI) Analysis Without Control DNA in a Brazilian Population: Correlation with Ancestry Markers
Campanella NC, Berardinelli GR, Scapulatempo-Neto C, Viana D, Palmero E, Pereira R, Reis RM. Optimization of a Pentaplex Panel for MicroSatellite Instability...
Read morePhenoWorld: a new paradigm to screen rodent behavior
Castelhano-Carlos M, Costa PS, Russig H, Sousa N. PhenoWorld: a new paradigm to screen rodent behavior. Translational Psychiatry 4:e399 (2014)
Read moreT Cell Activation Regulates CD6 Alternative Splicing by Transcription Dynamics and SRSF1
da Glória VG, Martins de Araújo M, Mafalda Santos A, Leal R, de Almeida SF, Carmo AM, Moreira A. T Cell Activation Regulates CD6 Alternative Splicing by...
Read morePavlovian conditioning and cross-sensitization studies raise challenges to the hypothesis that overeating is an addictive behavior
Harb MR, Almeida OF. Pavlovian conditioning and cross-sensitization studies raise challenges to the hypothesis that overeating is an addictive...
Read moreReference Values for Arterial Measurements Collaboration. Establishing reference values for central blood pressure and its amplification in a general healthy population and according to cardiovascular risk factors
Herbert A, Cruickshank JK, Laurent S, Boutouyrie P. Reference Values for Arterial Measurements Collaboration. Establishing reference values for central blood pressure...
Read moreMicrotubule-associated protein tau is essential for long-term depression in the hippocampus
Kimura T, Whitcomb DJ, Jo J, Regan P, Piers T, Heo S, Brown C, Hashikawa T, Murayama M, Seok H, Sotiropoulos I, Kim E, Collingridge GL, Takashima A, Cho K...
Read moreAstrocyte pathology in the prefrontal cortex impairs the cognitive function of rats
Lima A, Sardinha VM, Oliveira AF, Reis M, Mota C, Silva MA, Marques F, Cerqueira JJ, Pinto L, Sousa N, Oliveira JF. Astrocyte pathology in the prefrontal cortex...
Read moreNeuropathology of stress
Lucassen PJ, Pruessner J, Sousa N, Almeida OF, Van Dam AM, Rajkowska G, Swaab DF, Czéh B. Neuropathology of stress. Acta Neuropathologica...
Read moreThe Sweet Drive Test: refining phenotypic characterization of anhedonic behavior in rodents
Mateus-Pinheiro A, Patrício P, Alves ND, Machado-Santos AR, Morais M, Bessa JM, Sousa N, Pinto L. The Sweet Drive Test: refining phenotypic characterization of...
Read moreLipocalin 2 modulates the cellular response to amyloid beta
Mesquita SD, Ferreira AC, Falcao AM, Sousa JC, Oliveira TG, Correia-Neves M, Sousa N, Marques F, Palha JA. Lipocalin 2 modulates the cellular response to amyloid...
Read moreSerotonin 2C receptor antagonists induce fast-onset antidepressant effects
Opal MD, Klenotich SC, Morais M, Bessa J, Winkle J, Doukas D, Kay LJ, Sousa N, Dulawa SM. Serotonin 2C receptor antagonists induce fast-onset antidepressant...
Read moreImmunoglobulin genes implicated in glioma risk
Pandey JP, Kaur N, Costa S, Amorim J, Nabico R, Linhares P, Vaz R, Viana-Pereira M, Reis RM. Immunoglobulin genes implicated in glioma...
Read moreThe future is now: early life events preset adult behavior
Patchev AV, Rodrigues AJ, Sousa N, Spengler D, Almeida OF. The future is now: early life events preset adult behavior. Acta Physiologica...
Read moreThe role of pain catastrophizing in the provision of rescue analgesia by health care providers following major joint arthroplasty
Pinto P, McIntyre T, Araujo-Soares V, Ferro R, Almeida A. The role of pain catastrophizing in the provision of rescue analgesia by health care providers...
Read moreThe Big Five default brain: functional evidence
Sampaio A, Soares JM, Coutinho J, Sousa N, Gonçalves ÓF. The Big Five default brain: functional evidence. Brain Structure and Function...
Read moreHeterozygous deletion of the Williams-Beuren syndrome critical interval in mice recapitulates most features of the human disorder
Segura-Puimedon M, Sahún I, Velot E, Dubus P, Borralleras C, Rodrigues AJ, Valero MC, Valverde O, Sousa N, Herault Y, Dierssen M, Pérez-Jurado LA, Campuzano...
Read moreFrom basics to clinical: A comprehensive review on spinal cord injury
Silva NA, Sousa N, Reis RL, Salgado AJ. From basics to clinical: A comprehensive review on spinal cord injury. Progress in Neurobiology...
Read moreThe motivational drive to natural rewards is modulated by prenatal glucocorticoid exposure
Soares-Cunha C, Coimbra B, Borges S, Carvalho MM, Rodrigues AJ, Sousa N. The motivational drive to natural rewards is modulated by prenatal glucocorticoid...
Read moreSelective impact of Tau loss on nociceptive primary afferents and pain sensation
Sotiropoulos I, Lopes AT, Pinto V, Lopes S, Carlos S, Duarte-Silva S, Neves-Carvalho A, Pinto-Ribeiro F, Pinheiro S, Fernandes R, Almeida A, Sousa N...
Read moreIn Vitro Evaluation of Cell-Seeded Chitosan Films for Peripheral Nerve Tissue Engineering
Wrobel S, Serra SC, Ribeiro-Samy S, Sousa N, Heimann C, Barwig C, Grothe C, Salgado AJ, Haastert-Talini K. In Vitro Evaluation of Cell-Seeded Chitosan Films...
Read moreTLR2-induced IL-10 production impairs neutrophil recruitment to infected tissues during neonatal bacterial sepsis
Andrade EB, Alves J, Madureira P, Oliveira L, Ribeiro A, Cordeiro-da-Silva A, Correia-Neves M, Trieu-Cuot P, Ferreira P. TLR2-induced IL-10 production impairs...
Read moreAdenosine A(2A) receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation
Batalha VL, Pego JM, Fontinha BM, Costenla AR, Valadas JS, Baqi Y, Radjainia H, Müller CE, Sebastião AM, Lopes LV. Adenosine A(2A) receptor blockade reverts...
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