Neurosciences

The Neurosciences Research Domain (NeRD) aims to understand neural structure and function in normal conditions and disease, using a multidisciplinary and integrative approach, from fundamental to clinical studies. Our scientists strive to comprehend how complex neural circuits work, how these are shaped and reshaped during life by different environmental factors and how this drives behaviour. Also, we are focused on understanding the neurobiological mechanisms implicated in several neurodevelopmental and neurodegenerative disorders, as well as in evaluating the interplay between the nervous and the immune systems.

 

ICVS

Neurosciences Publications

Sorting nexin 3 mutation impairs development and neuronal function in Caenorhabditis elegans

Vieira N, Bessa C, Rodrigues AJ, Marques P, Chan FY, de Carvalho AX, Correia-Neves M, Sousa N. Sorting nexin 3 mutation impairs development and neuronal function in...

Read more

Endolysosomal degradation of Tau and its role in glucocorticoid-driven hippocampal malfunction

Vaz-Silva J, Gomes P, Jin Q, Zhu M, Zhuravleva V, Quintremil S, Meira T, Silva J, Dioli C, Soares-Cunha C, Daskalakis NP, Sousa N, Sotiropoulos I, Waites CL...

Read more

Inflammatory pathology markers (activated microglia and reactive astrocytes) in early and late onset Alzheimer disease: a post mortem study

Taipa R, Ferreira V, Brochado P, Robinson A, Reis I, Marques F, Mann DM, Melo-Pires M, Sousa N. Inflammatory pathology markers (activated microglia and reactive...

Read more

Brain morphometric profiles and their seasonal modulation in fish (Liza aurata) inhabiting a mercury contaminated estuary

Puga S, Cardoso V, Pinto-Ribeiro F, Pacheco M, Almeida A, Pereira P. Brain morphometric profiles and their seasonal modulation in fish (Liza aurata) inhabiting a...

Read more

Emotional distress in haemophilia: Factors associated with the presence of anxiety and depression symptoms among adults

Pinto PR, Paredes AC, Moreira P, Fernandes S, Lopes M, Carvalho M, Almeida A. Emotional distress in haemophilia: Factors associated with the presence of anxiety and...

Read more

Psychological factors predict an unfavorable pain trajectory after hysterectomy: a prospective cohort study on chronic post-surgical pain

Pinto PR, McIntyre T, Araújo-Soares V, Almeida A, Costa P. Psychological factors predict an unfavorable pain trajectory after hysterectomy: a prospective cohort study...

Read more

Dichotomous parvalbumin interneuron populations in dorsolateral and dorsomedial striatum

Monteiro P, Barak B, Zhou Y, McRae R, Rodrigues D, Wickersham IR, Feng G. Dichotomous parvalbumin interneuron populations in dorsolateral and dorsomedial...

Read more

Neuronal lysosomal dysfunction releases exosomes harboring APP C-terminal fragments and unique lipid signatures

Miranda AM, Lasiecka ZM, Xu Y, Neufeld J, Shahriar S, Simoes S, Chan RB, Oliveira TG, Small SA, Di Paolo G. Neuronal lysosomal dysfunction releases exosomes harboring...

Read more

Disruption of the β1L isoform of GABP reverses glioblastoma replicative immortality in a TERT promoter mutation-dependent manner

Mancini A, Xavier-Magalhães A, Woods WS, Nguyen KT, Amen AM, Hayes JL, Fellmann C, Gapinske M, McKinney AM, Hong C, Jones LE, Walsh KM, Bell RJA, Doudna JA, Costa BM...

Read more

The dynamics of stress: a longitudinal MRI study of rat brain structure and connectome

Magalhães R, Barrière DA, Novais A, Marques F, Marques P, Cerqueira J, Sousa JC, Cachia A, Boumezbeur F, Bottlaender M, Jay TM, Mériaux S, Sousa N. The dynamics of...

Read more

WNT6 is a Novel Oncogenic Prognostic Biomarker in Human Glioblastoma

Gonçalves CS, Vieira de Castro J, Pojo M, Martins EP, Queirós S, Chautard E, Taipa R, Pires MM, Pinto AA, Pardal F, Custódia C, Faria CC, Clara C, Reis RM, Sousa N...

Read more

Co-Transplantation of Adipose Tissue-Derived Stromal Cells and Olfactory Ensheathing Cells for Spinal Cord Injury Repair

Gomes ED, Mendes SS, Assunção-Silva RC, Teixeira FG, Pires AO, Anjo SI, Manadas B, Leite-Almeida H, Gimble JM, Sousa N, Lepore AC, Silva NA, Salgado AJ...

Read more

Lipocalin-2 regulates adult neurogenesis and contextual discriminative behaviours

Ferreira AC, Santos T, Sampaio-Marques B, Novais A, Mesquita SD, Ludovico P, Bernardino L, Correia-Neves M, Sousa N, Palha JA, Sousa JC, Marques F. Lipocalin-2...

Read more

Preclinical evidence supporting early initiation of citalopram treatment in Machado-Joseph disease

Esteves S, Oliveira S, Duarte-Silva S, Cunha-Garcia D, Teixeira-Castro A, Maciel P. Preclinical evidence supporting early initiation of citalopram treatment in...

Read more

Functional Hemispheric (A)symmetries in the Aged Brain-Relevance for Working Memory

Esteves M, Magalhães R, Marques P, Castanho TC, Portugal-Nunes C, Soares JM, Almeida A, Santos NC, Sousa N, Leite-Almeida H. Functional Hemispheric (A)symmetries in...

Read more

Neuroprotective Effects of Creatine in the CMVMJD135 Mouse Model of Spinocerebellar Ataxia Type 3

Duarte-Silva S, Neves-Carvalho A, Soares-Cunha C, Silva JM, Teixeira-Castro A, Vieira R, Silva-Fernandes A, Maciel P. Neuroprotective Effects of Creatine in the...

Read more

Impairments in laterodorsal tegmentum to VTA projections underlie glucocorticoid-triggered reward deficits

Coimbra B, Soares-Cunha C, Borges S, Sousa N, Rodrigues AJ. Impairments in laterodorsal tegmentum to VTA projections underlie glucocorticoid-triggered reward...

Read more

Time matters in multiple sclerosis: can early treatment and long-term follow-up ensure everyone benefits from the latest advances in multiple sclerosis?

Cerqueira JJ, Compston DAS, Geraldes R, Rosa MM, Schmierer K, Thompson A, Tinelli M, Palace J. Time matters in multiple sclerosis: can early treatment and long-term...

Read more

Chronic stress targets adult neurogenesis preferentially in the suprapyramidal blade of the rat dorsal dentate gyrus.

Alves ND, Patrício P, Correia JS, Mateus-Pinheiro A, Machado-Santos AR, Loureiro-Campos E, Morais M, Bessa JM, Sousa N, Pinto L. Chronic stress targets adult...

Read more

Intra-axonal Synthesis of SNAP25 Is Required for the Formation of Presynaptic Terminals

Batista AFR, Martinez JC, Hengst U. Intra-axonal Synthesis of SNAP25 Is Required for the Formation of Presynaptic Terminals. Cell Reports...

Read more

Adenosine A2A receptor regulation of microglia morphological remodeling-gender bias in physiology and in a model of chronic anxiety

Caetano L, Pinheiro H, Patrício P, Mateus-Pinheiro A, Alves ND, Coimbra B, Baptista FI, Henriques SN, Cunha C, Santos AR, Ferreira SG, Sardinha VM...

Read more

Impairments in laterodorsal tegmentum to VTA projections underlie glucocorticoid triggered reward deficits

Coimbra B, Soares-Cunha C, Borges S, Vasconcelos NAP, Sousa N, Rodrigues AJ. Impairments in laterodorsal tegmentum to VTA projections underlie glucocorticoid...

Read more

Tau-dependent suppression of adult neurogenesis in the stressed hippocampus

Dioli C, Patrício P, Trindade R, Pinto LG, Silva JM, Morais M, Ferreiro E, Borges S, Mateus-Pinheiro A, Rodrigues AJ, Sousa N, Bessa JM, Pinto L, Sotiropoulos I...

Read more

Structural laterality is associated with cognitive and mood outcomes: An assessment of 105 healthy aged volunteers

Esteves M, Marques P, Magalhães R, Castanho TC, Soares JM, Almeida A, Santos NC, Sousa N, Leite-Almeida H. Structural laterality is associated with cognitive and mood...

Read more

Discovery of Therapeutic Approaches for Polyglutamine Diseases: A Summary of Recent Efforts

Esteves S, Duarte-Silva S, Maciel P. Discovery of Therapeutic Approaches for Polyglutamine Diseases: A Summary of Recent Efforts. Medicinal Research Reviews...

Read more

Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory

Leroy F, Brann DH, Meira T, Siegelbaum SA. Input-Timing-Dependent Plasticity in the Hippocampal CA2 Region and Its Potential Role in Social Memory. Neuron...

Read more

Tau Deletion Prevents Stress-Induced Dendritic Atrophy in Prefrontal Cortex: Role of Synaptic Mitochondria

Lopes S, Teplytska L, Vaz-Silva J, Dioli C, Trindade R, Morais M, Webhofer C, Maccarrone G, Almeida OFX, Turck CW, Sousa N, Sotiropoulos I, Filiou...

Read more

Identification of octopaminergic neurons that modulate sleep suppression by male sex drive

Machado DR, Afonso DJ, Kenny AR, Öztu Rk-Çolak A, Moscato EH, Mainwaring B, Kayser M, Koh K. Identification of octopaminergic neurons that modulate sleep suppression...

Read more

Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine Glioma

Mackay A, Burford A, (…) Reis RM, (…) Resnick A, Jones C. Integrated Molecular Meta-Analysis of 1,000 Pediatric High-Grade and Diffuse Intrinsic Pontine...

Read more

AP2γ controls adult hippocampal neurogenesis and modulates cognitive, but not anxiety or depressive-like behavior

Mateus-Pinheiro A, Alves ND, Patricio P, Machado-Santos AR, Campos E, Silva J, Sardinha V, Reis, J, Schorle H, Oliveira JF, Ninkovic J, Sousa N, Pinto L...

Read more

SHANK proteins: roles at the synapse and in autism spectrum disorder

Monteiro P, Feng G. SHANK proteins: roles at the synapse and in autism spectrum disorder. Nature Reviews Neuroscience 18(3):147-157 (2017)

Read more

Brain interference: Revisiting the role of IFNγ in the central nervous system

Monteiro S, Roque S, Marques F, Correia-Neves M, Cerqueira JJ. Brain interference: Revisiting the role of IFNγ in the central nervous system. Progress in...

Read more

Microfluidic immunosensor for rapid and highly-sensitive salivary cortisol quantification

Pinto V, Sousa P, Catarino SO, Correia-Neves M, Minas G. Microfluidic immunosensor for rapid and highly-sensitive salivary cortisol...

Read more

Old and new challenges in Parkinson’s disease therapeutics

Pires AO, Teixeira FG, Mendes-Pinheiro B, Serra SC, Sousa N, Salgado AJ. Old and new challenges in Parkinson’s disease therapeutics. Progress in...

Read more

The choroid plexus as a sex hormone target: Functional implications

Santos CR, Duarte AC, Quintela T, Tomás J, Albuquerque T, Marques F, Palha JA, Gonçalves I. The choroid plexus as a sex hormone target: Functional...

Read more

Astrocytic signaling supports hippocampal–prefrontal theta synchronization and cognitive function

Sardinha VM, Guerra-Gomes S, Caetano I, Tavares G, Martins M, Reis JS, Correia JS, Teixeira-Castro A, Pinto L, Sousa N, Oliveira JF. Astrocytic signaling...

Read more

Mesenchymal Stem Cell Secretome: A Potential Tool for the Prevention of Muscle Degenerative Changes Associated With Chronic Rotator Cuff Tears

Sevivas N, Teixeira FG, Portugal R, Araújo L, Carriço LF, Ferreira N, Vieira da Silva M, Espregueira-Mendes J, Anjo S, Manadas B, Sousa N, Salgado AJ...

Read more

Distribution of amyloid-like and oligomeric species from protein aggregation kinetics

Silva A, Almeida B, Fraga JS, Taboada P, Martins PM, Macedo-Ribeiro S. Distribution of amyloid-like and oligomeric species from protein aggregation...

Read more

Calcineurin Dysregulation Underlies Spinal Cord Injury-Induced K+ Channel Dysfunction in DRG Neurons

Zemel BM, Muqeem T, Brown EV, Goulão M, Urban MW, Tymanskyj SR, Lepore AC, Covarrubias M. Calcineurin Dysregulation Underlies Spinal Cord Injury-Induced K+...

Read more

S100B as a Potential Biomarker and Therapeutic Target in Multiple Sclerosis

Barateiro A, Afonso V, Santos G, Cerqueira JJ, Brites D, van Horssen J, Fernandes A. S100B as a Potential Biomarker and Therapeutic Target in Multiple...

Read more

The prognostic impact of TERT promoter mutations in glioblastomas is modified by the rs2853669 single nucleotide polymorphism

Batista R, Cruvinel-Carloni A, Vinagre J, Peixoto J, Catarino TA, Campanella NC, Menezes W, Becker AP, Caravina GA, Matsushita MM, Clara C, Neder...

Read more

Repeated administration of a synthetic cannabinoid receptor agonist differentially affects cortical and accumbal neuronal morphology in adolescent and adult rats

Carvalho AF, Reyes BA, Ramalhosa F, Sousa N, Van Bockstaele EJ. Repeated administration of a synthetic cannabinoid receptor agonist differentially...

Read more

Combination of a peptide-modified gellan gum hydrogel with cell therapy in a lumbar spinal cord injury animal model

Gomes ED, Mendes SS, Leite-Almeida H, Gimble JM, Tam RY, Shoichet MS, Sousa N, Silva NA, Salgado AJ. Combination of a peptide-modified gellan gum hydrogel with...

Read more

Protein Prenylation Constitutes an Endogenous Brake on Axonal Growth

Li H, Kuwajima T, Oakley D, Nikulina E, Hou J, Yang WS, Lowry ER, Lamas NJ, Amoroso MW, Croft GF, Hosur R, Wichterle H, Sebti S, Filbin MT, Stockwell B...

Read more

Identification of novel genetic causes of Rett syndrome-like phenotypes

Lopes F, Barbosa M, Ameur A, Soares G, de Sá J, Dias AI, Oliveira G, Cabral P, Temudo T, Calado E, Cruz IF, Vieira JP, Oliveira R, Esteves S, Sauer S, Jonasson...

Read more

Absence of Tau triggers age-dependent sciatic nerve morphofunctional deficits and motor impairment

Lopes S, Lopes A, Pinto V, Guimarães MR, Sardinha MR, Duarte-Silva S, Pinheiro S, Pizarro J, Oliveira JF, Sousa N, Leite-Almeida H, Sotiropoulos I. Absence of...

Read more

Tau protein is essential for stress-induced brain pathology

Lopes S, Vaz-Silva J, Pinto V, Dalla C, Kokras N, Bedenk B, Mack N, Czisch  M, Almeida OFX, Sousa N, Sotiropoulos I. Tau protein is essential for...

Read more

Insights on the pathophysiology of Alzheimer’s disease: the crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system

Mesquita SD, Ferreira AC, Sousa JC, Correia-Neves M, Sousa N, Marques F. Insights on the pathophysiology of Alzheimer’s disease: the crosstalk between amyloid...

Read more

Absence of IFNg promotes hippocampal plasticity and enhances cognitive performance

Monteiro S, Ferreira FM, Pinto V, Roque S, Sá-Calçada D, Morais M, Sousa N, Correia-Neves M, Cerqueira JJ. Absence of IFNg promotes hippocampal plasticity and...

Read more

Identifying Functional Subdivisions in the Medial Frontal Cortex

Moreira PS, Marques P, Magalhães R. Identifying Functional Subdivisions in the Medial Frontal Cortex. Journal of Neuroscience 36(44):11168-11170 (2016)

Read more

The impact of chronic stress on the rat brain lipidome

Oliveira TG, Chan RB, Bravo FV, Miranda A, Silva RR, Zhou B, Marques F, Pinto V, Cerqueira JJ, Di Paolo G, Sousa N. The impact of chronic stress on the...

Read more

Tau mislocation in glucocorticoid-triggered hippocampal pathology

Pinheiro S, Silva J, Mota C, Vaz-Silva J, Veloso A, Pinto V, Sousa N, Cerqueira J, Sotiropoulos I. Tau mislocation in glucocorticoid-triggered hippocampal...

Read more

Activation of D2 dopamine receptor-expressing neurons in the nucleus accumbens increases motivation

Soares-Cunha C, Coimbra B, David-Pereira A, Borges S, Pinto L, Costa P, Sousa N, Rodrigues AJ. Activation of D2 dopamine receptor-expressing neurons in the nucleus...

Read more

Reappraising striatal D1- and D2-neurons in reward and aversion

Soares-Cunha C, Coimbra B, Sousa N, Rodrigues AJ. Reappraising striatal D1- and D2-neurons in reward and aversion. Neuroscience and Biobehavioral Reviews...

Read more

The dynamics of the stress neuromatrix

Sousa N. The dynamics of the stress neuromatrix. Molecular Psychiatry 21(3):302-312 (2016)

Read more

Modulation of the Mesenchymal Stem Cell Secretome Using Computer-Controlled Bioreactors: Impact on Neuronal Cell Proliferation, Survival and Differentiation

Teixeira FG, Panchalingam KM, Assunção-Silva R, Serra SC, Mendes-Pinheiro B, Patrício P, Jung S, Anjo SI, Manadas B, Pinto L, Sousa N, Behie LA...

Read more

Bioengineered cell culture systems of central nervous system injury and disease

Teixeira FG, Vasconcelos NL, Gomes ED, Marques F, Sousa JC, Sousa N, Silva NA, Assunção-Silva R, Lima R, Salgado AJ. Bioengineered cell culture systems of...

Read more

Recurrent copy number variations as risk factors for neurodevelopmental disorders: critical overview and analysis of clinical implications

Torres F, Barbosa M, Maciel P. Recurrent copy number variations as risk factors for neurodevelopmental disorders: critical overview and analysis of clinical...

Read more

TARANIS Functions with Cyclin A and Cdk1 in a Novel Arousal Center to Control Sleep in Drosophila

Afonso DJS, Liu D, Machado DR, Pan H, Jepson JEC, Rogulja D, Koh K. TARANIS Functions with Cyclin A and Cdk1 in a Novel Arousal Center to Control Sleep in...

Read more

The effect of high fat diet on rat’s mood, feeding behavior and response to stress

Aslani S, Vieira N, Marques F, Costa PS, Sousa N, Palha JA. The effect of high fat diet on rat’s mood, feeding behavior and response to stress. Translational...

Read more

Methylation at the CpG island shore region upregulates Nr3c1 promoter activity after early-life stress

Bockmühl Y, Patchev AV, Madejska A, Hoffmann A, Sousa JC, Sousa N, Holsboer F, Almeida OFX, Spengler D. Methylation at the CpG island shore region upregulates...

Read more

The Role of the Mammalian DNA End-processing Enzyme Polynucleotide Kinase 3′-Phosphatase in Spinocerebellar Ataxia Type 3 Pathogenesis

Chatterjee A, Saha S, Silva-Fernandes A, Mandal SM, Neves-Carvalho A, Liu Y, Pandita RK, Chakraborty A, Hegde ML, Hegde PM, Boldogh I, Ashizawa T, Koeppen...

Read more

Silencing of the tumor suppressor gene WNK2 is associated with upregulation of MMP2 and JNK in gliomas

Costa AM, Pinto F, Martinho O, Oliveira MJ, Jordan P, Reis RM. Silencing of the tumor suppressor gene WNK2 is associated with upregulation of MMP2 and JNK...

Read more

From the periphery to the brain: lipocalin-2, a friend or foe?

Ferreira AC, Mesquita SD, Sousa JC, Correia-Neves M, Sousa N, Palha JA, Marques F. From the periphery to the brain: lipocalin-2, a friend or foe? Progress...

Read more

Inactivation of PNKP by mutant ATXN3 triggers apoptosis by activating the DNA damage-response pathway in SCA3

Gao R, Liu Y, Silva-Fernandes A, Paulucci-Holthauzen A, Chatterjee A, Zhang H, Mattsura T, Fang X, Choudhary S, Ashizawa T, Koeppen A, Maciel P, Hazra TK...

Read more

Brain activation of the defensive and appetitive survival systems in obsessive compulsive disorder

Gonçalves OF, Soares JM, Carvalho S, Leite J, Ganho A, Fernandes-Gonçalves A, Frank B, Pocinho F, Relvas J, Carracedo A, Sampaio A. Brain activation of the...

Read more

The bounds of education in the human brain connectome

Marques P, Soares JM, Magalhães R, Santos NC, Sousa N. The bounds of education in the human brain connectome. Scientific Reports...

Read more

The positive effect on ketamine as a priming adjuvant in antidepressant treatment

Melo A, Kokras N, Dalla C, Ferreira C, Ventura-Silva AP, Sousa N, Pêgo JM. The positive effect on ketamine as a priming adjuvant in antidepressant...

Read more

The choroid plexus transcriptome reveals changes in type I and II interferon responses in a mouse model of Alzheimer’s Disease

Mesquita SD, Ferreira AC, Gao F, Coppola G, Geschwind DH, Sousa JC, Correia-Neves M, Sousa N, Palha JA, Marques F. The choroid plexus transcriptome...

Read more

Lipids under stress – a lipidomic approach for the study of mood disorders

Miranda AM, Oliveira TG. Lipids under stress – a lipidomic approach for the study of mood disorders. Bioessays 37(11):1226-1235 (2015)

Read more

Dominant negative effect of polyglutamine expansion perturbs normal function of ataxin-3 in neuronal cells

Neves-Carvalho A, Logarinho E, Freitas A, Duarte-Silva S, Costa MC, Silva-Fernandes A, Martins M, Cravino Serra S, Lopes A, Paulson HL...

Read more

Do stars govern our actions? Astrocyte involvement in rodents’ behavior

Oliveira J, Sardinha V, Guerra-Gomes S, Araque A, Sousa N. Do stars govern our actions? Astrocyte involvement in rodents’ behavior. Trends in Neurosciences...

Read more

Differential and converging molecular mechanisms of antidepressants action in the hippocampal dentate gyrus.

Patrício P, Mateus-Pinheiro A, Irmler M, Alves ND, Machado-Santos AR, Morais M, Correia JS, Korostynski M, Piechota M, Stoffel R, Beckers J, Bessa JM...

Read more

Differential impact of chronic stress along the hippocampal dorsal-ventral axis

Pinto V, Costa JC, Morgado P, Mota C, Miranda A, Bravo FV, Oliveira TG, Cerqueira JJ, Sousa N. Differential impact of chronic stress along the hippocampal...

Read more

Expression of histone methyltransferases as novel biomarkers for renal cell tumor diagnosis and prognostication

Pires-Luís AS, Vieira-Coimbra M, Vieira FQ, Costa-Pinheiro P, Silva-Santos R, Dias PC, Antunes L, Lobo F, Oliveira J, Gonçalves CS, Costa BM, Henrique R...

Read more

A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide.

Pojo M, Gonçalves CS, Xavier-Magalhães A, Oliveira AI, Gonçalves T, Correia S, Rodrigues AJ, Costa S, Pinto L, Pinto AA, Lopes JM, Reis RM, Rocha...

Read more

Novel candidate blood-based transcriptional biomarkers of Machado-Joseph disease (MJD/SCA3).

Raposo M, Bettencourt C, Gao F, Ramos A, Kazachkova N, Vasconcelos J, Kay T, Rodrigues AJ, Maciel P, Bettencourt B, Bruges-Armas J, Geschwind D, Coppola G...

Read more

Serotonergic signalling suppresses ataxin-3 aggregation and neurotoxicity in animal models of Machado-Joseph disease

Teixeira-Castro A, Jalles AL, Esteves S, Kang S, Santos L, Silva-Fernandes A, Neto M, Brielmann RM, Bessa C, Miranda A, Oliveira...

Read more

Optimization of a Pentaplex Panel for MicroSatellite Instability (MSI) Analysis Without Control DNA in a Brazilian Population: Correlation with Ancestry Markers

Campanella NC, Berardinelli GR, Scapulatempo-Neto C, Viana D, Palmero E, Pereira R, Reis RM. Optimization of a Pentaplex Panel for MicroSatellite Instability...

Read more

PhenoWorld: a new paradigm to screen rodent behavior

Castelhano-Carlos M, Costa PS, Russig H, Sousa N. PhenoWorld: a new paradigm to screen rodent behavior. Translational Psychiatry 4:e399 (2014)

Read more

T Cell Activation Regulates CD6 Alternative Splicing by Transcription Dynamics and SRSF1

da Glória VG, Martins de Araújo M, Mafalda Santos A, Leal R, de Almeida SF, Carmo AM, Moreira A. T Cell Activation Regulates CD6 Alternative Splicing by...

Read more

Pavlovian conditioning and cross-sensitization studies raise challenges to the hypothesis that overeating is an addictive behavior

Harb MR, Almeida OF. Pavlovian conditioning and cross-sensitization studies raise challenges to the hypothesis that overeating is an addictive...

Read more

Reference Values for Arterial Measurements Collaboration. Establishing reference values for central blood pressure and its amplification in a general healthy population and according to cardiovascular risk factors

Herbert A, Cruickshank JK, Laurent S, Boutouyrie P. Reference Values for Arterial Measurements Collaboration. Establishing reference values for central blood pressure...

Read more

Microtubule-associated protein tau is essential for long-term depression in the hippocampus

Kimura T, Whitcomb DJ, Jo J, Regan P, Piers T, Heo S, Brown C, Hashikawa T, Murayama M, Seok H, Sotiropoulos I, Kim E, Collingridge GL, Takashima A, Cho K...

Read more

Astrocyte pathology in the prefrontal cortex impairs the cognitive function of rats

Lima A, Sardinha VM, Oliveira AF, Reis M, Mota C, Silva MA, Marques F, Cerqueira JJ, Pinto L, Sousa N, Oliveira JF. Astrocyte pathology in the prefrontal cortex...

Read more

Neuropathology of stress

Lucassen PJ, Pruessner J, Sousa N, Almeida OF, Van Dam AM, Rajkowska G, Swaab DF, Czéh B. Neuropathology of stress. Acta Neuropathologica...

Read more

The Sweet Drive Test: refining phenotypic characterization of anhedonic behavior in rodents

Mateus-Pinheiro A, Patrício P, Alves ND, Machado-Santos AR, Morais M, Bessa JM, Sousa N, Pinto L. The Sweet Drive Test: refining phenotypic characterization of...

Read more

Lipocalin 2 modulates the cellular response to amyloid beta

Mesquita SD, Ferreira AC, Falcao AM, Sousa JC, Oliveira TG, Correia-Neves M, Sousa N, Marques F, Palha JA. Lipocalin 2 modulates the cellular response to amyloid...

Read more

Serotonin 2C receptor antagonists induce fast-onset antidepressant effects

Opal MD, Klenotich SC, Morais M, Bessa J, Winkle J, Doukas D, Kay LJ, Sousa N, Dulawa SM. Serotonin 2C receptor antagonists induce fast-onset antidepressant...

Read more

Immunoglobulin genes implicated in glioma risk

Pandey JP, Kaur N, Costa S, Amorim J, Nabico R, Linhares P, Vaz R, Viana-Pereira M, Reis RM. Immunoglobulin genes implicated in glioma...

Read more

The future is now: early life events preset adult behavior

Patchev AV, Rodrigues AJ, Sousa N, Spengler D, Almeida OF. The future is now: early life events preset adult behavior. Acta Physiologica...

Read more

The role of pain catastrophizing in the provision of rescue analgesia by health care providers following major joint arthroplasty

Pinto P, McIntyre T, Araujo-Soares V, Ferro R, Almeida A. The role of pain catastrophizing in the provision of rescue analgesia by health care providers...

Read more

The Big Five default brain: functional evidence

Sampaio A, Soares JM, Coutinho J, Sousa N, Gonçalves ÓF. The Big Five default brain: functional evidence. Brain Structure and Function...

Read more

Heterozygous deletion of the Williams-Beuren syndrome critical interval in mice recapitulates most features of the human disorder

Segura-Puimedon M, Sahún I, Velot E, Dubus P, Borralleras C, Rodrigues AJ, Valero MC, Valverde O, Sousa N, Herault Y, Dierssen M, Pérez-Jurado LA, Campuzano...

Read more

From basics to clinical: A comprehensive review on spinal cord injury

Silva NA, Sousa N, Reis RL, Salgado AJ. From basics to clinical: A comprehensive review on spinal cord injury. Progress in Neurobiology...

Read more

The motivational drive to natural rewards is modulated by prenatal glucocorticoid exposure

Soares-Cunha C, Coimbra B, Borges S, Carvalho MM, Rodrigues AJ, Sousa N. The motivational drive to natural rewards is modulated by prenatal glucocorticoid...

Read more

Selective impact of Tau loss on nociceptive primary afferents and pain sensation

Sotiropoulos I, Lopes AT, Pinto V, Lopes S, Carlos S, Duarte-Silva S, Neves-Carvalho A, Pinto-Ribeiro F, Pinheiro S, Fernandes R, Almeida A, Sousa N...

Read more

In Vitro Evaluation of Cell-Seeded Chitosan Films for Peripheral Nerve Tissue Engineering

Wrobel S, Serra SC, Ribeiro-Samy S, Sousa N, Heimann C, Barwig C, Grothe C, Salgado AJ, Haastert-Talini K. In Vitro Evaluation of Cell-Seeded Chitosan Films...

Read more

TLR2-induced IL-10 production impairs neutrophil recruitment to infected tissues during neonatal bacterial sepsis

Andrade EB, Alves J, Madureira P, Oliveira L, Ribeiro A, Cordeiro-da-Silva A, Correia-Neves M, Trieu-Cuot P, Ferreira P. TLR2-induced IL-10 production impairs...

Read more

Adenosine A(2A) receptor blockade reverts hippocampal stress-induced deficits and restores corticosterone circadian oscillation

Batalha VL, Pego JM, Fontinha BM, Costenla AR, Valadas JS, Baqi Y, Radjainia H, Müller CE, Sebastião AM, Lopes LV. Adenosine A(2A) receptor blockade reverts...

Read more