Microbiology & Infection

The Microbiology and Infection Research Domain (MIRD) aims to pioneer the identification of prognostic, diagnostic and therapeutic targets for the development of personalized medical interventions for infectious diseases. The global burden of infectious diseases, still a leading cause of death and disability worldwide, is magnified by persistent infections, epidemics of new and old infectious diseases, the increasing number of immunocompromised patients and the increased number of hospitals acquired infections. The MIRD tackle these challenges by two main complementary strategies: i) basic research to understand biological mechanisms and to identify novel targets for prognostic/diagnostics and therapy and ii) translational research that explores relevant biological processes in patients.

 

ICVS

Microbiology & Infection Publications

Tolerance has its limits: how the thymus copes with infection

Nunes-Alves C, Nobrega C, Behar SM, Correia-Neves M. Tolerance has its limits: how the thymus copes with infection. Trends in Immunology...

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Calcium sequestration by fungal melanin inhibits calcium-calmodulin signalling to prevent LC3-associated phagocytosis

Kyrmizi I, Ferreira H, Carvalho A, Figueroa JAL, Zarmpas P, Cunha C, Akoumianaki T, Stylianou K, Deepe GS Jr, Samonis G, Lacerda JF, Campos A Jr...

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The troika host- pathogen- extrinsic factors in tuberculosis: modulating inflammation and clinical outcomes

Bastos HN, Osório NS, Gagneux S, Comas I, Saraiva M. The troika host- pathogen- extrinsic factors in tuberculosis: modulating inflammation and clinical...

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Interleukin-6 neutralization by antibodies immobilized at the surface of polymeric nanoparticles as a therapeutic strategy for arthritic diseases

Lima AC, Cunha C, Carvalho A, Ferreira H, Neves NM. Interleukin-6 neutralization by antibodies immobilized at the surface of polymeric nanoparticles as a...

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The anti-caspase inhibitor Q-VD-OPH prevents Aids disease progression in SIV-infected rhesus macaques

Laforge M, Silvestre R, Rodrigues V, Garibal J, Campillo-Gimenez L, Mouhamad S, Monceaux V, Cumont MC, Rabezanaha H, Pruvost A, Cordeiro-da-Silva A, Hurtrel B...

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Plasmodium falciparum Plasmepsin 2 Duplications, West Africa

Inoue J, Silva M, Fofana B, Sanogo K, Mårtensson A, Sagara I, Björkman A, Veiga MI, Ferreira PE, Djimde A, Gil JP. Plasmodium falciparum Plasmepsin 2...

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Genetic deficiency of NOD2 confers resistance to invasive aspergillosis

Gresnigt MS, Cunha C, Jaeger M, Gonçalves SM, Subbarao Malireddi RK, Ammerdorffer A, Lubbers R, Oosting M, Rasid O, Jouvion G, Fitting C, de Jong DJ...

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L-threonine supplementation during colitis onset delays disease recovery

Gaifem J, Gonçalves LG, Dinis-Oliveira RJ, Cunha C, Carvalho A, Torrado E, Rodrigues F, Saraiva M, Castro AG, Silvestre R. L-threonine supplementation...

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Toward the identification of a genetic risk signature for pulmonary aspergillosis in chronic obstructive pulmonary disease

Cunha C, Carvalho A. Toward the identification of a genetic risk signature for pulmonary aspergillosis in chronic obstructive pulmonary disease. Clinical...

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Dosage of single low-dose primaquine to stop malaria transmission

Cruz M, Sánchez IM, Diaz J, Cuevas F, Silva M, Disla M, Ferreira PE, Veiga MI. Dosage of single low-dose primaquine to stop malaria...

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Guidelines and recommendations on yeast cell death nomenclature

Carmona-Gutierrez D, Bauer MA (…), Ludovico P, (…), Kroemer G, Madeo F. Guidelines and recommendations on yeast cell death nomenclature. Microbial Cell...

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The dynamics of Interleukin-10-afforded protection during Dextran Sulfate Sodium -induced colitis

Cardoso A, Gil Castro A, Martins AC, Carriche GM, Murigneux V, Castro I, Cumano A, Vieira P, Saraiva M. The dynamics of Interleukin-10-afforded protection during...

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Host genetic signatures of susceptibility to fungal disease

Campos CF, van de Veerdonk FL, Gonçalves SM, Cunha C, Netea MG, Carvalho A. Host genetic signatures of susceptibility to fungal disease. Current Topics...

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The troika host- pathogen- extrinsic factors in tuberculosis: modulating inflammation and clinical outcomes

Bastos HN, Osório NS, Gagneux S, Comas I, Saraiva M. The troika host- pathogen- extrinsic factors in tuberculosis: modulating inflammation and clinical...

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Increasing the Fungicidal Action of Amphotericin B by Inhibiting the Nitric Oxide-Dependent Tolerance Pathway

Vriens K,Kumar PT, Struyfs C,Cool TL, Spincemaille P, Kokalj T, Sampaio-Marques B, Ludovico P, Lammertyn J,Cammue BPA, Thevissen K. Increasing the Fungicidal...

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Hexahydroquinolines are Antimalarial Candidates with Potent Blood Stage and Transmission-Blocking Activity

Vanaerschot M, Lucantoni L, LiT, Combrinck J, Ruecker A, Kumar TR, Rubiano K, Ferreira PE, Siciliano G,Gulati S, Henrich P, Ng C, Murithi J, Corey V, Duffy...

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High systemic IL-6 is associated with worse prognosis in patients with non-small cell lung cancer

Silva EM,Mariano VS, Pastrez PRA, Pinto MC, Castro AG, Syrjanen KJ, Longatto-Filho A. High systemic IL-6 is associated with worse prognosis in patients with...

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Innate IFN-γ-Producing cells developing in the absence of IL-2 receptor commonγ-chain

ResendeM, Cardoso MS,Ribeiro AR, Flórido M, Borges M, Castro AG, Alves NL, Cooper AM, Appelberg R.Innate IFN-γ-Producing cells developing in the absence of IL-2...

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CD4 T Follicular Helper Cells and HIV Infection:Friends or Enemies?

Moukambi F,Rodrigues V,Fortier Y, Rabezanahary H, Borde C, Krust B, Andreani G, Silvestre R, Petrovas C, Laforge M, Estaquier J. CD4 T Follicular Helper Cells...

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Yeaston the corner of life and death decisions

Ludovico P, Côrte-Real M.Yeaston the corner of life and death decisions. Mechanisms of Ageing and Development161(Pt B):199-200 (2017)

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Drivers of genetic diversity in secondary metabolic geneclusters within a fungal species

Lind AL,Wisecaver JH, Lameiras C, Wiemann P, Palmer JM, Keller NP, Rodrigues F,Goldman GH, Rokas A. Drivers of genetic diversity in secondary metabolic...

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Caloric restriction alleviates alpha-synuclein toxicity in aged yeastcells by controlling the opposite roles of Tor1 and Sir2 on autophagy

GuedesA, Ludovico P, Sampaio-Marques B. Caloric restriction alleviates alpha-synuclein toxicity in aged yeastcells by controlling the opposite roles of Tor1 and Sir2...

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The absence of NOD1 enhanceskilling of Aspergillus fumigatus through modulationof dectin-1 expression

Gresnigt MS, Jaeger M, Subbarao Malireddi RK, Rasid O, Jouvion G, Fitting C, Melchers W,Kanneganti TD, Carvalho A, Ibrahim-Granet O, van de Veerdonk FL.The...

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Evaluation of bronchoalveolar lavage fluid cytokines as biomarkers for invasive pulmonary aspergillosis in at-risk patients

Gonçalves SM, Lagrou K, Rodrigues CS, Campos CF, Bernal-Martínez L, Rodrigues F, Silvestre R, Alcazar-Fuoli L, Maertens JA, Cunha...

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The microbiome-metabolome crosstalk in the pathogenesis of respiratory fungaldiseases

Gonçalves SM, Lagrou K, Duarte-Oliveira C, Maertens JA, Cunha C, Carvalho A. The microbiome-metabolome crosstalk in the pathogenesis of...

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Impactof Paracoccin Gene Silencing on Paracoccidioidesbrasiliensis Virulence

Fernandes FF, Oliveira AF, Landgraf TN, Cunha C,Carvalho A, Vendruscolo PE, Gonçales RA, Almeida F, da Silva TA, Rodrigues F, Roque-Barreira...

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The Cell Biology of the Trichosporon-Host Interaction

Duarte-Oliveira C, Rodrigues F, Gonçalves SM, Goldman GH, Carvalho A, Cunha C. The Cell Biology of the Trichosporon-Host Interaction. Frontiers in Cellular...

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Natural based eumelanin nanoparticles functionalization and preliminary evaluation as carrier for gentamicin

De Trizio A, Srisuk P, Costa RR, Fraga AG,Modena T, Genta I, Dorati R, Pedrosa J, Conti B, Correlo VM, Reis RL. Natural based eumelanin nanoparticles...

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IL-10 overexpression predisposes to invasive aspergillosis by suppressing antifungal immunity

Cunha C, Gonçalves SM, Duarte-Oliveira C, Leite L,Lagrou K, Marques A,Lupiañez CB, Mesquita I, Gaifem J, Barbosa AM,Pinho Vaz C, Branca R, Campilho F, Freitas F...

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Cell sheet engineering using the stromal vascular fraction of adipose tissue as a vascularization strategy

Costa M, Cerqueira MT, Santos TC, Sampaio-Marques B, Ludovico P, Marques AP, Pirraco RP, Reis RL. Cell sheet engineering using the stromal vascular...

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The influence of surface modified poly(l-lactic acid)films on the differentiation of human monocytes into macrophages

Correia CR, Gaifem J, Oliveira MB, Silvestre R, Mano JF. The influence of surface modified poly(l-lactic acid)films on the differentiation of human...

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Vasculogenesis and Diabetic Erectile Dysfunction:How Relevant Is Glycemic Control?

Castela A,Gomes P, Silvestre R, Guardão L, Leite L, Chilro R, Rodrigues I,Vendeira P, Virag R, Costa C. Vasculogenesis and Diabetic Erectile Dysfunction:How...

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Editorial: An Omics Perspective on Fungal Infection: Toward Next-Generation Diagnosis and Therapy

Carvalho A, GoldmanGH.Editorial: An Omics Perspective on Fungal Infection: Toward Next-Generation Diagnosis and Therapy. Frontiers in Microbiology...

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Platelet Lysate-Loaded Photocrosslinkable Hyaluronic Acid Hydrogels for Periodontal Endogenous Regenerative Technology.

Babo PS, Pires RL, Santos L, Franco A, Rodrigues F, Leonor I, Reis RL, Gomes ME. Platelet Lysate-Loaded Photocrosslinkable Hyaluronic Acid Hydrogels...

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Mycobacterium tuberculosis Complex Exhibits Lineage-Specific Variations Affecting Protein Ductility and Epitope Recognition

Yruela I,Contreras-Moreira B, Magalhães C, Osório NS,Gonzalo-Asensio J. Mycobacterium tuberculosis Complex Exhibits Lineage-Specific Variations Affecting...

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Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies

Veiga MI, Dhingra SK, Henrich PP, Straimer J,Gnädig N, Uhlemann AC, Martin RE, Lehane AM, Fidock DA. Globally prevalent PfMDR1 mutations modulate Plasmodium...

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Delivery of LLKKK18 loaded into self-assembling hyaluronic acid nanogel for tuberculosis treatment

Silva JP, Gonçalves C, Costa C, Sousa J, Silva-Gomes R, Castro AG, Pedrosa J, Appelberg R, Gama FM. Delivery of LLKKK18 loaded into self-assembling...

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Interleukin-27 Early Impacts Leishmania infantum Infection in Mice and Correlates with Active Visceral Disease in Humans

Pérez-Cabezas B, Cecílio P, Robalo A, Silvestre R, Carrillo E, Moreno J, San Martín JV, Vasconcellos R and Cordeiro-da-Silva A. Interleukin-27 Early Impacts...

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Ca2+monitoring in Plasmodium falciparum using the yellow cameleon-Nanobiosensor

Pandey K, Ferreira PE, Ishikawa T, Nagai T, Kaneko O, Yahata K. Ca2+monitoring in Plasmodium falciparum using the yellow...

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Exploring NAD+metabolism in host-pathogen interactions

Mesquita I, Varela P, Belinha A,Gaifem J, Laforge M, Vergnes B, Estaquier J, Silvestre R.Exploring NAD+metabolism in host-pathogen...

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Polymorphisms in host immunity modulating genes and risk of invasive aspergillosis: results from the aspBIOmics consortium

Lupiañez CB, Canet LM, Carvalho A, Alcazar-Fuoli L, Springer J, Lackner M,Segura-Catena J, Comino A, Olmedo C, Ríos R,Fernandez-Montoya A,Cuenca-Estrella M...

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NF-κB pathway controls mitochondrial dynamics

Laforge M, Rodrigues V, Silvestre R, Gautier C,Weil R, Corti O, Estaquier J. NF-κB pathway controls mitochondrial dynamics. Cell Death and Differentiation...

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Klionsky DJ, Abdelmohsen, K,(…), Ludovico P, (…) Zorzano A,Zughaier SM. Guidelines for the use and interpretation of assays for monitoring autophagy...

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Genetic Determinants of Drug Resistance in Mycobacterium tuberculosis and Their Diagnostic Value

Farhat MR,Sultana R, Iartchouk O, Bozeman S, Galagan J, Sisk P, Stolte C, Nebenzahl-Guimaraes H, Jacobson K,Sloutsky A, Kaur D, Posey J, Kreiswirth BN, Kurepina...

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Prevalence and factors associated to Diabetes mellitus among Tuberculosispatients – Anationwide cohort

Cordeiro da Costa J, Baia L, Gaio R, Oliveira O, Correia-Neves M, Duarte R. Prevalence and factors associated to Diabetes mellitus among...

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The soluble pattern recognition receptor PTX3 linkshumoral innate and adaptive immune responses by helping marginal zone Bcells

Chorny A, Casas-Recasens S,Sintes J, Shan M, Polentarutti N,García-Escudero R, Walland AC, Yeiser JR,Cassis L, Carrillo J, Puga I, Cunha C, Bastos H, Rodrigues...

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Antibacterial bioadhesive layer-by-layer coatings for orthopedic applications

Carvalho AL, Vale AC, Sousa MP, Barbosa AM, Torrado E, Mano JF, Alves NM. Antibacterial bioadhesive layer-by-layer coatings for orthopedic...

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A Higher Activation Threshold of Memory CD8+ TCells Has a Fitness Cost That Is Modified by TCR Affinity during Tuberculosis

Carpenter SM, Nunes-Alves C, Booty MG, Way SS, Behar SM. A Higher Activation Threshold of Memory CD8+ TCells Has a Fitness Cost That Is Modified by TCR Affinity...

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Genetic variation in autophagy-related genes influences the risk and phenotype of Buruli ulcer

Capela C, Dossou AD, Silva-Gomes R, Sopoh GE,Makoutode M, Menino JF, Fraga AG, Cunha C, Carvalho A, Rodrigues F, Pedrosa J. Genetic variation in...

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Glutaminolysis and fumarate accumulation integrate immunometabolic and epigenetic programs in trained immunity

Arts RJ, Novakovic B, ter Horst R, Carvalho A,Bekkering S, Lachmandas E, Rodrigues F, Silvestre R,Cheng SC,Wang SY, Habibi E, Gonçalves...

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Immunometabolic Pathways in BCG-Induced Trained Immunity

Arts RJ, Carvalho A, La Rocca C, Palma C, Rodrigues F, Silvestre R, Kleinnijenhuis J, Lachmandas E, Gonçalves LG, Belinha A, Cunha C, Oosting...

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Spontaneous healing of Mycobacterium ulcerans lesions in the guinea pig model

Silva-Gomes R, Marcq E, Trigo G, Gonçalves CM, Longatto-Filho A, Castro AG, Pedrosa J, Fraga AG. Spontaneous healing of Mycobacterium ulcerans lesions in the guinea...

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Ammonium is a key determinant on the dietary restriction of yeast chronological aging in culture medium

Santos J, Leitão-Correia F, Sousa MJ, LeãoC. Ammonium is a key determinant on the dietary restriction of yeast chronological aging in culture...

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Paving the way for predictive diagnostics and personalized treatment of invasive aspergillosis

Oliveira-Coelho A, Rodrigues F, Campos Jr. A, Lacerda JF, Carvalho A, Cunha C. Paving the way for predictive diagnostics and personalized treatment of invasive...

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Human and murineclonal CD8+ T cell expansions arise during tuberculosis because of TCR selection

Nunes-Alves C, Booty MG, Carpenter S, Rothchild AC, Martin CJ, Desjardins D, Steblenko K,Kløverpris HN, Madansein R, Ramsuran D, Leslie A, Correia-Neves M,Behar...

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Transmission and Progression to Disease of Mycobacterium tuberculosis Phylogenetic Lineages in The Netherlands

Nebenzahl-Guimaraes H, Verhagen LM,Borgdorff MW, van Soolingen D. Transmission and Progression to Disease of Mycobacterium tuberculosis Phylogenetic Lineages in The...

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Early loss of splenic Tfh cells in SIV-infected rhesus macaques

Moukambi F,Rabezanahary H, Rodrigues V, Racine G, Robitaille L, Krust B, Andreani G, Soundaramourty C, Silvestre R, Laforge M, Estaquier J. Early loss of splenic...

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To Be or Not to Be a Pseudogene: A Molecular Epidemiological Approach to the mclx Genes and Its Impact in Tuberculosis

LopesSantos C, Nebenzahl-Guimaraes H, Mendes MV, van Soolingen D, Correia-Neves M. To Be or Not to Be a Pseudogene: A Molecular Epidemiological Approach to the...

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A Gβ protein and the TupA Co-Regulator Bind to Protein Kinase A Tpk2 to Act as Antagonistic Molecular Switches of Fungal Morphological Changes

Janganan TK, Chen G, Chen D, Menino JF, Rodrigues F,Borges-Walmsley MI, Walmsley AR. A Gβ protein and the TupA Co-Regulator Bind to Protein Kinase A Tpk2 to...

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Mosaic maternal ancestry in the Great Lakes region of East Africa

Gomes V, Pala M, Salas A, Álvarez-Iglesias V, Amorim A,Gómez-Carballa A, Carracedo Á, Clarke DJ, Hill C, Mormina M, Shaw MA, Dunne DW, Pereira R, Pereira V, Prata MJ...

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A breakthrough on Amanita phalloides poisoning: an effective antidotal effect bypolymyxin B

Garcia J,Costa VM, Carvalho AT, Silvestre R, Duarte JA, Dourado DF, Arbo MD,Baltazar T, Dinis-Oliveira RJ, Baptista P, de Lourdes Bastos M, Carvalho F. A...

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Proteolytic systems and AMP-activated protein kinase are critical targets of acute myeloid leukemiatherapeutic approaches

Fernandes Â, Azevedo MM, Pereira O, Sampaio-Marques B, Paiva A, Correia-Neves M, Castro I, Ludovico P. Proteolytic systems and AMP-activated...

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PTX3-based genetic testing for risk of aspergillosis after lung transplant

Cunha C, Monteiro AA, Oliveira-Coelho A,Kühne J, Rodrigues F, Sasaki SD, Schio SM, Camargo JJ, Mantovani A, Carvalho A, Pasqualotto AC. PTX3-based...

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BCG vaccination-induced long-lasting control of Mycobacterium tuberculosis correlates with the accumulation of a novel population of CD4+IL-17+TNF+IL-2+ T cells

Cruz A,Torrado E, Carmona J, Fraga AG, Costa P, Rodrigues F, Appelberg R, Correia-Neves M, Cooper AM, Saraiva M, Pedrosa J, Castro AG. BCG...

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Promising blood-derived biomarkers for estimation of the postmortem interval

Costa I, Carvalho F, Magalhães T, Pinho PG, Silvestre R, Dinis-Oliveira RJ. Promising blood-derived biomarkers for estimation of the postmortem...

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Analysis of a local HIV-1 epidemic in Portugal highlights established transmission of non-Band non-G subtypes

Carvalho A, Costa P, Triunfante V, Branca F, Rodrigues F, Santos CL, Correia-Neves M, Saraiva M, Lecour H, Castro AG, Pedrosa J, Osório...

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Lack of the transcription factor hypoxia-inducible factor(HIF)-1α in macrophages accelerates the necrosis of Mycobacterium avium-induced granulomas

Cardoso MS,Silva TM, Resende M, Appelberg R, Borges M. Lack of the transcription factor hypoxia-inducible factor(HIF)-1α in macrophages accelerates the necrosis...

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Clinical epidemiology of Buruli ulcer from Benin(2005-2013): effect of time-delay to diagnosis on clinical forms and severe phenotypes

Capela C,Sopoh GE, Houezo JG, Fiodessihoué R, Dossou AD, Costa P, Fraga AG, Menino JF,Silva-Gomes R, Ouendo EM, Rodrigues F, Pedrosa J. Clinical...

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Tuberculosis and HIV coinfection

Bruchfeld J, Correia-Neves M, Källenius G. Tuberculosis and HIV coinfection. Cold Spring Harbor Perspectives in Medicine 5(7):a017871 (2015)

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The Warburg effect in mycobacterial granulomas is dependent on the recruitment and activation of macrophages by gamma interferon

Appelberg R, Moreira D, Barreira-Silva P, Borges M, Silva L, Dinis-Oliveira RJ, Resende M, Correia-Neves M, Jordan M, Ferreira N, Abrunhosa...

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Complex Polymorphisms in the Plasmodium falciparum Multidrug Resistance Protein 2 Gene and Its Contribution to Antimalarial Response

Veiga MI, Osório NS, Ferreira PE, Franzén O,Dahlstrom S, Lum JK, Nosten F, Gil JP. Complex Polymorphisms in the Plasmodium falciparum Multidrug Resistance...

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Differential post-transcriptional regulation of IL-10 by TLR2and TLR4-activated macrophages

Teixeira-Coelho M, Guedes J, Ferreirinha P, Howes A, Pedrosa J, Rodrigues F, Lai WS, Blackshear PJ, O’Garra A, Castro AG, Saraiva M. Differential...

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iNKT Cell Production of GM- CSF Controls Mycobacterium tuberculosis

Rothchild AC, Jayaraman P, Nunes-Alves C, Behar SM. iNKT Cell Production of GM- CSF Controls Mycobacterium tuberculosis. PLOS Pathogens...

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The behavioral and immunological impact of maternal separation: a matter of timing

Roque S,Mesquita AR, Palha JA, Sousa N, Correia-Neves M. The behavioral and immunological impact of maternal separation: a matter of timing. Frontiers in...

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In search of a new paradigm for protective immunity to TB

Nunes-Alves C, Booty MG,Carpenter SM, Jayaraman P, Rothchild AC, Behar SM. In search of a new paradigm for protective immunity to TB.Nature Reviews Microbiology...

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Systematic review of allelic exchange experiments aimed at identifying mutations that confer drug resistance in Mycobacteriumtuberculosis

Nebenzahl-Guimaraes H, Jacobson KR,Farhat MR, Murray MB. Systematic review of allelic exchange experiments aimed at identifying mutations that confer drug resistance...

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A Novel Approach – The Propensity to Propagate(PTP) Method for Controlling for Host Factors in Studying the Transmission of Mycobacterium Tuberculosis

Nebenzahl-Guimaraes H, Borgdorff MW,Murray MB, van Soolingen D. A Novel Approach – The Propensity to Propagate(PTP) Method for Controlling for Host Factors in...

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Prevalence of Bovine Tuberculosis and Risk Factor Assessment in Cattle in Rural Livestock Areas of Govuro District in the Southeast of Mozambique

Moiane I, Machado A, Santos N,Nhambir A, Inlamea O, Hattendorf J, Kallenius G, Zinsstag J, Correia-Neves M. Prevalence of Bovine Tuberculosis and Risk...

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The Genome Sequence of the Highly Acetic Acid-Tolerant Zygosaccharomyces bailii-Derived Interspecies Hybrid Strain ISA1307, Isolated From a Sparkling Wine Plant

Mira NP,Münsterkötter M, Dias-Valada F, Santos J, Palma M, Roque FC,Guerreiro JF, Rodrigues F, Sousa MJ, Leão C,Güldener U, Sá-Correia I. The...

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Lipocalin 2 modulates the cellular response to amyloid beta

Mesquita SD,Ferreira AC, Falcao AM, Sousa JC, OliveiraTG, Correia-Neves M, Sousa N, Marques F, Palha JA. Lipocalin 2 modulates the cellular response to amyloid...

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Type I IFN Induces IL-10 Production in anIL-27–Independent Manner and Blocks Responsiveness to IFN-g for Production ofIL-12 and Bacterial Killing in Mycobacterium tuberculosis–Infected Macrophages

McNab FW, Ewbank J, Howes A, Moreira-Teixeira L, Martirosyan A, Ghilardi N,Saraiva M, O’Garra A. Type I IFN Induces IL-10 Production in anIL-27–Independent...

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Reactive oxygen species, ageing and the hormesis police

Ludovico P, Burhans WC.Reactive oxygen species, ageing and the hormesis police. FEMS Yeast Research 14(1):33-39 (2014)

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Single nucleotide polymorphisms in Plasmodium falciparum V type H+ pyrophosphatase gene (pfvp2) and their associations with pfcrt and pfmdr1 polymorphisms

Jovel IT, Ferreira PE, Veiga MI, Malmberg M, MårtenssonA, Kaneko A, Zakeri S, Murillo C, Nosten F, Björkman A, Ursing J. Single nucleotide polymorphisms in...

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Proteomic Analysis of the Action of the Mycobacterium ulcerans Toxin Mycolactone: Targeting Host Cells Cytoskeleton and Collagen

Gama JB,Ohlmeier S, Martins TG, Fraga AG, Sampaio-Marques B, Carvalho MA,Proenca F , Silva MT, Pedrosa J, Ludovico P. Proteomic Analysis of the Action of...

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The Regulation of IL-10 Expression

Gabryšová L, Howes A, Saraiva M, O’Garra A. The Regulation of IL-10 Expression. Interleukin-10 in Health and Disease: Current Topics in Microbiology...

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A bacteriophage detection tool for viability assessment of Salmonella cells

Fernandes E, Martins VC, Nóbrega C, Carvalho CM, Cardoso FA,Cardoso S, Dias J, Deng D, Kluskens LD, Freitas PP, Azeredo J. A bacteriophage detection tool for...

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Neutrophil responses to aspergillosis: new roles for old players

Cunha C, Kurzai O, Löffler J, Aversa F,Romani L, Carvalho A. Neutrophil responses to aspergillosis: new roles for old players. Mycopathologia...

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Genetic PTX3 Deficiency and Aspergillosis in Stem-Cell Transplantation

Cunha C, Aversa F, Lacerda JF, Busca A, Kurzai O,Grube M, Loffler J,Maertens JA, Bell AS, Inforzato A, Barbati E, Almeida B,Sousa PSE, Barbui A,Potenza L, Caira...

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Functional characterization of a xylose transporter in Aspergillus nidulans

Colabardini AC, Ries LN, Brown NA, Dos Reis TF, Savoldi M, Goldman MH, Menino JF, Rodrigues F, Goldman GH. Functional characterization of a xylose...

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DNA replication stress-induced loss of reproductive capacity in S. cerevisiae and its inhibition by caloric restriction

Weinberger M, Sampaio-Marques B, Ludovico P, Burhans WC. DNA replication stress-induced loss of reproductive capacity in S. cerevisiae and its inhibition by...

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PhageTherapy Is Effective against Infection by Mycobacterium ulcerans in a Murine Footpad Model

Trigo G,Martins TG, Fraga AG, Longatto-Filho A, Castro AG, Azeredo J, Pedrosa J. PhageTherapy Is Effective against Infection by Mycobacterium ulcerans in a...

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Genome-wide identification of genes involved in the positive and negative regulation of acetic acid-induced programmed cell death in Saccharomyces cerevisiae

Sousa M, Duarte AM, Fernandes TR, Chaves SR, Pacheco A, Leão C, Côrte-Real M, Sousa MJ. Genome-wide identification of genes involved in the positive and...

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C2-phytoceramide perturbs lipid rafts and cell integrity in Saccharomyces cerevisiae in asterol-dependent manner

Pacheco A, Azevedo F, Rego A, Santos J, Chaves SR, Côrte-Real M, Sousa MJ. C2-phytoceramide perturbs lipid rafts and cell integrity in Saccharomyces...

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Evidence for diversifying selection in a set of Mycobacterium tuberculosis genes in response to antibiotic and non-antibiotic related pressure

Osório NS, Rodrigues F,Gagneux S, Pedrosa J, Pinto-Carbó M, Castro AG, Young D, Comas I, Saraiva M. Evidence for diversifying selection in a set of...

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T Cells Home to the Thymus and Control Infection

Nóbrega C, Nunes-Alves C, Cerqueira-Rodrigues B, Roque S,Barreira-Silva P, Behar SM, Correia-Neves M. T Cells Home to the Thymus and Control...

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P.brasiliensis Virulence Is Affected by SconC, the Negative Regulator of Inorganic Sulfur Assimilation

Menino JF, Saraiva M, Gomes-Rezende J, Sturme M, Pedrosa J, Castro AG, Ludovico P, Goldman GH, Rodrigues F. P.brasiliensis Virulence Is Affected by SconC, the...

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TLR9 Activation Dampens the Early Inflammatory Response to Paracoccidioides brasiliensis, Impacting Host Survival

Menino JF, Saraiva M, Gomes-Alves AG, Lobo-Silva D,Sturme M, Gomes-Rezende J, Saraiva AL, Goldman GH, Cunha C,Carvalho A, Romani L,Pedrosa J, Castro AG...

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TPL-2-ERK1/2 Signaling Promotes Host Resistance against Intracellular Bacterial Infection by Negative Regulation of Type I IFN Production

McNab FW,Ewbank J, Rajsbaum R, Stavropoulos E, Martirosyan A, Redford PS, Wu X, Graham CM, Saraiva M, Tsichlis P, Chaussabel D, Ley SC, O’Garra...

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Poor Immune Reconstitution in HIV-Infected Patients Associates with High Percentage of Regulatory CD4(+) T Cells

Horta A, Nobrega C, Amorim-Machado P, Coutinho-Teixeira V, Barreira-Silva P, Boavida S, Costa P, Sarmento-Castro R, Castro AG, Correia-Neves M. Poor Immune...

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Yeast between life and death: a summary of the Ninth International Meeting on Yeast Apoptosis in Rome, Italy, 17-20 September 2012

Guaragnella N, Palermo V, Burhans WC, Gourlay CW, Ludovico P, Madeo F,Giannattasio S, Mazzoni C. Yeast between life and death: a summary of the Ninth...

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Mycobacterium tuberculosis Strains Are Differentially Recognized by TLRs with an Impact on the Immune Response

CarmonaJ, Andrea C, Moreira-Teixeira L, Sousa C, Sousa J, Osorio NS, Saraiva AL, Svenson S, Kallenius G, Pedrosa J, Rodrigues F, Castro AG, Saraiva M...

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TLR2-induced IL-10 production impairs neutrophil recruitment to infected tissues during neonatal bacterial sepsis

Andrade EB, Alves J, Madureira P, Oliveira L, Ribeiro A,Cordeiro-da-Silva A, Correia-Neves M, Trieu-Cuot P, Ferreira P.TLR2-induced IL-10 production impairs...

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Lipoarabinomannan mannose caps do not affect mycobacterial virulence or the induction of protective immunity in experimental animal models of infection and have minimal impact on in vitro inflammatory responses

Afonso-Barroso A, Clark SO, Williams A, Rosa GT, Nóbrega C, Silva-Gomes S,Vale-Costa S, Ummels R, Stoker N, Movahedzadeh F, van der Ley P, Sloots A, CotM...

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pfmdr1 amplification is related to increased Plasmodium falciparum in vitrosensitivity to the bisquinoline piperaquine

Veiga Ml,Ferreira PE, Malmberg M, Jornhagen L, Bjorkman A, Nosten F, Gil JP. pfmdr1 amplification is related to increased Plasmodium falciparum in vitrosensitivity to...

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SNCA (a-synuclein)­ induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy

Sampaio-Marques B, Felgueiras C, Silva A, Rodrigues M, Tenreiro S, Franssens V, Reichert AS,Outeiro TF, Winderickx J, Ludovico P. SNCA (a-synuclein)­ induced toxicity...

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Differential arabinan capping of lipoarabinomannan modulates innate immune responses and impacts T helper cell Differentiation

Mishra AK,Alves JE, Krumbach K, Nigou J, Castro AG, Geurtsen J, Eggeling L, Saraiva M,Besra GS. Differential arabinan capping of lipoarabinomannan modulates...

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Modulation of iron metabolism in aging and in Alzheimer’s disease:relevance of the choroid plexus

Mesquita SD, Ferreira AC, Sousa JC, Santos NC, Correia-Neves M, Sousa N, Palha JA,Marques F. Modulation of iron metabolism in aging and in Alzheimer’s...

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Corticosteroid-Induced Immunosuppression Ultimately Does Not Compromise the Efficacy of Antibiotherapy in Murine Mycobacterium ulceransInfection

Martins TG,Trigo G, Fraga AG, Gama JB, Longatto-Filho A, Saraiva M, Silva MT, Castro AG,Pedrosa J. Corticosteroid-Induced Immunosuppression Ultimately Does...

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Efferocytosis Is an Innate Antibacterial Mechanism

Martin CJ,Booty MG, Rosebrock TR, Nunes-Alves C, Desjardins DM, Keren I, Fortune SM,Remold HG, Behar SM. Efferocytosis Is an Innate Antibacterial...

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Lipocalin2 is present in the EAE brain and is modulated by natalizumab

Marques F, Mesquita SD, Sousa JC, Coppola G, Gao F, Geschwind DH, Columba-Cabezas S, Aloisi F, Degn M, Cerqueira JJ, Sousa N,Correia-Neves M, Palha...

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CD4+ Tcell vaccination overcomes defective cross-presentation of fungal antigens in a mouse model of chronic granulomatous disease

Luca AD,lannitti RG, Bozza S, Beau R, Casagrande A, D’Angelo C, Moretti S, Cunha C,Giovannini G, Massi-Benedetti C, Carvalho A, Boon L, Latge JP, Romani L...

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From memory to antifungal vaccine design

lannittiRG, Carvalho A, Romani L. From memory to antifungal vaccine design. Trends in lmmunology 3(9):467-474 (2012)

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How “humane” is your end point?­Refining the science-driven approach for termination of animal studies of chronic infection

Franco NH, Correia-Neves M, Olsson IA. How “humane” is your end point?­Refining the science-driven approach for termination of animal studies of...

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Cellular Immunity Confers Transient Protection in Experimental Buruli Ulcer following BCG or Mycolactone-Negative Mycobacterium ulcerans Vaccination

Fraga AG,Martins TG, Torrado E, Huygen K, Portaels F, Silva MT, Castro AG, Pedrosa J.Cellular Immunity Confers Transient Protection in Experimental Buruli Ulcer...

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Yeast as a platform to uncover ceramide-induced ancient cell death routines

Costa V,Ludovico P. Yeast as a platform to uncover ceramide-induced ancient cell death routines. Cell Cycle 11(1):14-15 (2012)

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TLR3 essentially promotes protective class I-restricted memoryCD8(+) T-cell responses to Aspergillus fumigatus in hematopoietic transplanted patients

Carvalho A,De Luca A, Bozza S, Cunha C, D’ Angelo C, Moretti S, Perruccio K, lannitti RG,Fallarino F, Pierini A, Latge JP, Velardi A, Aversa F, Romani L. TLR3...

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Immunotherapy of aspergillosis

Carvalho A,Cunha C, Bistoni F, Romani L. Immunotherapy of aspergillosis. Clinical Microbiology and Infection 18(2):120-125 (2012)

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Molecular and Cellular Mechanisms of Mycobacterium avium-lnduced Thymic Atrophy

Borges M,Barreira-Silva P, Florido M, Jordan MB, Correia-Neves M, Appelberg R. Molecular and Cellular Mechanisms of Mycobacterium avium-lnduced Thymic...

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